The Southwest Institute for Research on Women (SIROW) had a number of successes in 2014, one of which is its partnership with the Pascua Yaqui Tribe. SIROW collaborates with the Pascua Yaqui Tribe on externally funded projects of importance - focusing on workforce development and health and well-being. SIROW’s iSTEM Project, funded by the National Science Foundation, provides mentoring and informal science experiences for students in grades 3rd - 8th with intent to engage Pascua Yaqui youth in STEM education and careers. The Ili Uusim Hiapsi (Heart of the Little Child) Project, funded by the Substance Abuse and Mental Health Services Administration (SAMHSA) is a Pascua Yaqui led systems improvement project that provides training programs for tribal staff serving families with children up to 8 years of age. In addition, the Pascua Yaqui System of Care Expansion Project, also funded by SAMHSA, aims to enhance and improve the Pascua Yaqui system of care for adolescents and their families. For the SAMHSA funded projects, SIROW conducts the evaluation component - contributing to knowledge of successful strategies for improvement at the individual, familial and system’s levels. These successful projects engage UA student workers, interns, graduate research assistance, and others in a dynamic learning experience while also expanding the UA’s land grant mission. The collaborative nature of SIROW’s projects is synergistic and contributes to our knowledge of regional needs and successful research-supported strategies to address these needs.